Are you taking this?

Dietary supplements are used by millions of Americans every day, often with the belief that “natural” means safe. But health experts are increasingly warning that one widely used supplement may interfere with several common prescription medications—sometimes reducing their effectiveness or increasing the risk of side effects.

Why Supplement Interactions Matter

Unlike prescription drugs, most supplements are available over the counter and are not regulated as strictly. This can lead many people to take them without discussing it with a doctor or pharmacist. According to medical professionals, that’s where problems can start.

Certain supplements can affect how the body absorbs, breaks down, or eliminates medications. In some cases, this may cause prescription drugs to become less effective. In others, it may increase the concentration of a drug in the bloodstream, raising the risk of unwanted reactions.

The Supplement Drawing Attention

One of the most commonly cited supplements for drug interactions is St. John’s wort, a herbal product often used for mood support and emotional well-being. While it has a long history of use, researchers have found that it can interfere with enzymes in the liver that process many medications.

As a result, people taking this supplement may experience unexpected changes in how their medications work.

Medications That May Be Affected

Health experts say this supplement may interfere with several widely prescribed drugs, including:

  • Antidepressants
  • Birth control pills
  • Blood thinners
  • Heart medications
  • Anti-seizure drugs
  • Certain cholesterol-lowering medications

In some cases, the interaction may reduce the medication’s effectiveness. In others, it could increase side effects or cause symptoms that are hard to explain.

Why Many People Don’t Realize the Risk

One major concern is that many patients don’t think to mention supplements during medical visits. Doctors say they frequently hear, “It’s just a vitamin” or “It’s natural,” even though supplements can act on the body in powerful ways.

Older adults, in particular, may be at higher risk because they are more likely to take multiple prescriptions at the same time.

What Health Professionals Recommend

Medical professionals generally advise patients to:

  • Tell their doctor about all supplements they take
  • Avoid starting a new supplement without medical guidance
  • Read labels carefully for warnings or interaction notices
  • Ask a pharmacist before combining supplements with prescriptions

Experts emphasize that supplements are not automatically harmful—but they should be treated with the same caution as medications.

The Bottom Line

Supplements can offer benefits for some people, but they are not risk-free. This popular supplement, in particular, has been shown to interfere with a range of common medications, sometimes in ways people don’t expect.

If you take prescription drugs or manage a chronic condition, health professionals strongly recommend discussing supplement use with a qualified medical provider. A simple conversation could help prevent complications and ensure your medications work as intended.

This article is for informational purposes only and does not replace professional medical advice. Always consult a healthcare provider with questions about medications or supplements.